Ph Do What!?

First a brief explanation of the title: canonical and non-canonical are concepts in cell signaling.  A canonical signaling pathway is a the "typical" way a signaling molecule works.  For example the "canonical" activity of a molecule called NLRP3 is to activate an enzyme called Caspase 1 which causes inflammation by activating a a pair of inflammatory molecules called interleukin-1β and interleukin-18.  This is the "canonical pathway" primarily because it is the pathway that we observe most often and is the one we found first.  The "non-canonical pathway" has NLRP3 activating a different enzyme called caspase 11 which has similar effects on inflammation, but also leads to a type of programmed cell death called "pyropoptosis." This idea is actually falling out of favor as we realize that signaling pathways aren't really straight line from A to B to C, but the nomenclature remains.  These days, calling something "non-canonical...